Heat inactivation by high temperature as an approach to combat infections caused by airborne pathogens

The current pandemic of SARS-CoV-2 coronavirus infection has highlighted the importance control measures to combat infections caused by airborne pathogens. Non-specific actions include various means microorganism inactivation chemical or physical methods targeting structural components a given pathogen. Exposure viruses and bacteria elevated temperatures is one effective for discharging their harmful potential. Using model Human Adenovirus 5 exposed with subsequent titration virus in vitro A549 cells, we showed dramatic decrease titer after heat treatment s at over 100°C. To verify potential closed environment, prototype high-capacity pathogen-cleaning device was constructed tested. Application 2 h an airflow rate 900 m 3 /h room 226 reduced total number microorganisms air more than 50% all collection sites room.